Structural characterization of quadruplex DNA with in-cell EPR approaches.


Guanosine-rich DNA sequences have the potential to adopt four-stranded conformations termed quadruplexes. The chromosomes of higher organisms are capped by so-called telomeres that are composed of repeats of the sequence TTAGGG. Up to 200 nucleotides of the G-rich strand form an overhang that is suspected to fold into intramolecular G-quadruplexes. Since… (More)
DOI: 10.1016/j.bmc.2013.04.014


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