Structural characterization of polymorphs and molecular complexes of finasteride

  title={Structural characterization of polymorphs and molecular complexes of finasteride},
  author={I. Wawrzycka and K. Stȩpniak and Sławomir Matyjaszczyk and A. Kozioł and T. Lis and K. Abboud},
  journal={Journal of Molecular Structure},
Abstract The molecular structure of finasteride, 17β-(N-tert-butylcarbamoyl)-4-aza-5α-androst-1-en-3-one, and structures of three related crystalline forms have been determined by X-ray analysis. The rigid steroid skeleton of the molecule adopts a half-chair/chair/chair/half-chair conformation. Two peptide groups, one cyclic (lactam) in the ring A and a second being a part of the substituent at C17, are the main factors influencing intermolecular contacts. Different hydrogen-bond interactions… Expand
Structural study of polymorphs and solvates of finasteride.
A ring conformation of androstan-3-one
Three isostructural solvates of finasteride and their solid-state characterization.
  • N. Schultheiss, J. P. Smit, J. Hanko
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2009
Comprehensive spectroscopic characterization of finasteride polymorphic forms. Does the form X exist?