Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies.

@article{Diswall2010StructuralCO,
  title={Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies.},
  author={Mette Diswall and Jonas {\AA}ngstr{\"o}m and Hasse Karlsson and Carol J. Phelps and David L. Ayares and Susann Teneberg and Michael E Breimer},
  journal={Xenotransplantation},
  year={2010},
  volume={17 1},
  pages={48-60}
}
BACKGROUND alpha1,3-galactosyltranferase knockout (GalT-KO) pigs have been established to avoid hyperacute rejection in GalT-KO pig-to-human xenotransplantation. GalT-KO pig heart and kidney glycolipids were studied focusing on elimination of Gal-antigens and whether novel antigens would appear. Non-human primates are used as pre-clinical transplantation experimental models. Therefore, sera from baboons transplanted with GalT-KO hearts were compared with human serum regarding reactivity with… CONTINUE READING