Structural characterization of glycans on omega-1, a major Schistosoma mansoni egg glycoprotein that drives Th2 responses.

@article{Meevissen2010StructuralCO,
  title={Structural characterization of glycans on omega-1, a major Schistosoma mansoni egg glycoprotein that drives Th2 responses.},
  author={Moniek H J Meevissen and Manfred Wuhrer and Michael J. Doenhoff and Gabriele Schramm and Helmut Haas and Andr{\'e} M. Deelder and Cornelis H. Hokke},
  journal={Journal of proteome research},
  year={2010},
  volume={9 5},
  pages={
          2630-42
        }
}
Soluble egg antigens (SEA) of the human parasite Schistosoma mansoni are among the strongest natural stimuli of Th2 responses. Omega-1, a major glycoprotein in SEA, initiates these characteristic Th2 responses through conditioning of dendritic cells (DCs). In view of the reported immunomodulatory potential of SEA glycans, we have investigated omega-1 glycosylation, using an approach combining mass spectrometric techniques and enzyme treatments at the glycopeptide level. We demonstrate that… 
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Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor
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