Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR.

Abstract

To understand the process of protein folding, it will be necessary to obtain detailed structural information on folding intermediates. This difficult problem is being studied by using hydrogen exchange and rapid mixing to label transient structural intermediates, with subsequent analysis of the proton-labelling pattern by two-dimensional nuclear magnetic… (More)

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@article{Roder1988StructuralCO, title={Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR.}, author={Heinrich Roder and G A El{\"o}ve and S. Walter Englander}, journal={Nature}, year={1988}, volume={335 6192}, pages={700-4} }