Structural characterization of electrochemically and in vitro biologically generated oxidation products of atorvastatin using UHPLC/MS/MS

@article{Jirsko2013StructuralCO,
  title={Structural characterization of electrochemically and in vitro biologically generated oxidation products of atorvastatin using UHPLC/MS/MS},
  author={Robert Jir{\'a}sko and Tom{\'a}{\vs} Mikysek and Vitaliy Chagovets and Ivan Vokř{\'a}l and Michal Hol{\vc}apek},
  journal={Analytical and Bioanalytical Chemistry},
  year={2013},
  volume={405},
  pages={7181-7193}
}
AbstractUltrahigh-performance liquid chromatography coupled with high-mass-accuracy tandem mass spectrometry (UHPLC–MS–MS) has been used for elucidation of the structures of oxidation products of atorvastatin (AT), one of the most popular commercially available drugs. The purpose of the study was identification of AT metabolites in rat hepatocytes and comparison with electrochemically generated oxidation products. AT was incubated with rat hepatocytes for 24 h. Electrochemical oxidation of AT… CONTINUE READING
BETA

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES