Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.

@article{Dey2005StructuralCO,
  title={Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.},
  author={Antu K Dey and Carla Griffiths and Susan M Lea and William James},
  journal={RNA},
  year={2005},
  volume={11 6},
  pages={873-84}
}
We recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind specifically to the surface glycoprotein (gp 120) of the R5 strain, HIV-1(Ba-L), as presented in a previous study. These aptamers potently neutralize HIV-1 infectivity in human peripheral blood mononuclear cells of both tissue culture lab-adapted strains and diverse R5 clinical isolates from multiple clades. Here, we report a detailed structural characterization of one such neutralizing aptamer, B40… CONTINUE READING

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