Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis

@inproceedings{Edwards2011StructuralCO,
  title={Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis},
  author={Thomas E Edwards and Ariel B Abramov and Eric R Smith and Ruth O. Baydo and Jess T Leonard and David J Leibly and Kaitlin B Thompkins and Matthew C. Clifton and Anna S. Gardberg and Bart L. Staker and Wesley C E Van Voorhis and Peter J. Myler and Lance J. Stewart},
  booktitle={BMC Structural Biology},
  year={2011}
}
Ribose-5-phosphate isomerase is an enzyme that catalyzes the interconversion of ribose-5-phosphate and ribulose-5-phosphate. This family of enzymes naturally occurs in two distinct classes, RpiA and RpiB, which play an important role in the pentose phosphate pathway and nucleotide and co-factor biogenesis. Although RpiB occurs predominantly in bacteria, here we report crystal structures of a putative RpiB from the pathogenic fungus Coccidioides immitis. A 1.9 Å resolution apo structure was… CONTINUE READING