Structural characterization and identification of biflavones in Selaginella tamariscina by liquid chromatography-diode-array detection/electrospray ionization tandem mass spectrometry.

  title={Structural characterization and identification of biflavones in Selaginella tamariscina by liquid chromatography-diode-array detection/electrospray ionization tandem mass spectrometry.},
  author={Yi-xuan Zhang and Qiu-yue Li and Li-Li Yan and Yue Shi},
  journal={Rapid communications in mass spectrometry : RCM},
  volume={25 15},
Biflavonoids, a special class of flavonoids, are widely distributed in gymnosperm plants and have various biological activities. They are also major bioactive ingredients in Selaginella tamariscina. In this work, we report the use of high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n)) to study the fragmentation behavior of three main types of biflavonoids using seven biflavonoid reference… 
Characterisation of homoflavonoids from three Ophioglossum species using liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry.
The HPLC-DAD-ESI/MS(n) method obtained in the present study provided a powerful tool for identifying homoflavonoids from ferns in the genus Ophioglossum.
Rapid Screening and Structural Characterization of Antioxidants from the Extract of Selaginella doederleinii Hieron with DPPH-UPLC-Q-TOF/MS Method
It is demonstrated that DPPH-UPLC-Q-TOF/MS exhibits strong capacity in separation and identification for small molecule, suitable for rapid screening of antioxidants without the need for complicated systems and additional instruments.
Structural characterization of phenolics and betacyanins in Gomphrena globosa by high-performance liquid chromatography-diode array detection/electrospray ionization multi-stage mass spectrometry.
This study significantly extends the knowledge of the G. globosa metabolome, by providing further insights into its phenolic composition, including the first time that tetrahydroxy-methylenedioxyflavone derivatives and acetylglycosides are described in nature.
Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects
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Identification of xanthones from Swertia punicea using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
The described methods were very valuable for the identification ofxanthones, especially of the trace compounds, and therefore could be utilized for sensitive and rapid qualitative analysis of xanthones in Swertia punicea.
Rapid screening and detection of XOD inhibitors from S. tamariscina by ultrafiltration LC-PDA–ESI-MS combined with HPCCC
The results reveal that the method for systematic screening, identification, and isolation of bioactive components in S. tamariscina is feasible and efficient, and could be expected to extend to screening and separation of other enzyme inhibitors.
Strong and Selective Inhibitory Effects of the Biflavonoid Selamariscina A against CYP2C8 and CYP2C9 Enzyme Activities in Human Liver Microsomes
It is concluded that selamariscina A has selective and strong inhibitory effects on the CYP 2C8 and CYP2C9 isoforms, which might be useful in predicting herb-drug interaction potential between biflavonoids and co-administered drugs mainly metabolized by CYP1A2 and CYB2C8.
Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia.


Structural characterization and identification of iridoid glycosides, saponins, phenolic acids and flavonoids in Flos Lonicerae Japonicae by a fast liquid chromatography method with diode-array detection and time-of-flight mass spectrometry.
A fast liquid chromatography method with diode-array detection (DAD) and time-of-flight mass spectrometry (TOF-MS) has been developed for analysis of constituents in Flos Lonicerae Japonicae (FLJ), a
A fragmentation study of dihydroquercetin using triple quadrupole mass spectrometry and its application for identification of dihydroflavonols in Citrus juices.
The established fragmentation patterns have been used to successfully identity three dihydroflavonols found in tangerine juices for the first time.
Development of an LC-MS method for simultaneous quantitation of amentoflavone and biapigenin, the minor and major biflavones from Hypericum perforatum L., in human plasma and its application to real blood.
The developed and validated method for determination of biflavones from human plasma was effectively applied to pharmacokinetic studies of 13 probands and preliminary results indicate biphasic concentration-time curves.
Electrospray ionization tandem mass spectrometry fragmentation of protonated flavone and flavonol aglycones: a re-examination.
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of flavone and flavonols aglycones finds that the losses of one and two CO molecules can be useful in terms of antioxidant activity prediction and structure and activity predictions.
Mass spectrometry in the structural analysis of flavonoids.
A review of currently available mass spectrometry methodology used in the structure elucidation of flavonoids is presented and sample preparation, liquid chromatographic/mass spectrometric analysis and tandem mass Spectrometric procedures for the characterization of flav onoid aglycones, O-glycosides, C-glyCosides and acylated glycosides are considered.
Liquid chromatography-tandem mass spectrometry of I3,II8-biapigenin, the major biflavone in Hypericum perforatum extracts.
  • M. Čolović, S. Caccia
  • Biology, Chemistry
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2008