Structural characteristics of potential novel virulence factors, the host cytokine binding proteins of Aggregatibacter actinomycetemcomitans


Various gram-negative pathogens possess secreted or outer membrane proteins (OMPs) which interact with host cytokines. Of periodontal pathogens only Aggregatibacter actinomycetemcomitans (Aa) has been shown to sequester and uptake cytokines. We have identified two (OMPs) of Aa, bacterial interleukin receptor I (BilRI) and OM secretin channel (OMS), which… (More)


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