Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities Applied modifications in the steroidal structure

@article{Fragkaki2009StructuralCO,
  title={Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities Applied modifications in the steroidal structure},
  author={Argyro G Fragkaki and Yiannis S Angelis and Michael A. Koupparis and Anna Tsantili-Kakoulidou and George Kokotos and Constantinos D Georgakopoulos},
  journal={Steroids},
  year={2009},
  volume={74},
  pages={172-197}
}
Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone introduced for therapeutic purposes providing enhanced anabolic potency with reduced androgenic effects. Androgens mediate their action through their binding to the androgen receptor (AR) which is mainly expressed in androgen target tissues, such as the prostate, skeletal muscle, liver and central nervous system. This paper reviews some of the wide spectrum of testosterone and synthetic AAS structure modifications… Expand
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