Structural characteristics and permeability properties of the human nail : A review

@inproceedings{Gupchup1999StructuralCA,
  title={Structural characteristics and permeability properties of the human nail : A review},
  author={Gouri V. Gupchup},
  year={1999}
}
The human nail forms a resistant barrier to the topical penetration of actives. Thus, treatment of nail disorders, such as fungal infections, remains a challenge because of the difficulty encountered in achieving therapeutic concentrations of drugs at the site of infection. The nail is primarily composed of a highly cross-linked keratin network that contains several disulfide linkages. This unique structure results in a highly effective permeability barrier. Nail penetration has been reported… CONTINUE READING

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