Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of alpha-tocopheryl esters.

@article{Kogure2004StructuralCO,
  title={Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of alpha-tocopheryl esters.},
  author={Kentaro Kogure and Susumu Hama and Mayumi Kisaki and Hideaki Takemasa and Akira Tokumura and Ichiro Suzuki and Kenji Fukuzawa},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1672 2},
  pages={
          93-9
        }
}
alpha-Tocopheryl succinate (TS) is known to induce apoptosis in various cells and has attracted attention as a chemotherapeutic agent. Recently, we reported the structural significance of the terminal dicarboxylic moiety for the action of TS [J. Nutr. Sci. Vitaminol. 49 (2003) 310-314]. In this study, to determine details of the relationship between the structure and the function of the terminal ester moiety of alpha-tocopherol (alpha-T), we synthesized four novel esters, alpha-tocopheryl… CONTINUE READING
BETA

Similar Papers

Loading similar papers…