Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

@inproceedings{Scopelliti2017StructuralCR,
  title={Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5},
  author={Amanda J. Scopelliti and Josep Font and Robert J Vandenberg and Olga Boudker and Renae M Ryan},
  booktitle={Nature Communications},
  year={2017}
}
Cancer cells undergo a shift in metabolism where they become reliant on nutrients such as the amino-acid glutamine. Glutamine enters the cell via the alanine/serine/cysteine transporter 2 (ASCT2) that is upregulated in several cancers to maintain an increased supply of this nutrient and are therefore an attractive target in cancer therapeutic development. ASCT2 belongs to the glutamate transporter (SLC1A) family but is the only transporter in this family able to transport glutamine. The… CONTINUE READING
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Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2

K Singh
Bioorg. Med. Chem. Lett. 27, • 2017

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