Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response.

@article{Huising2004StructuralCO,
  title={Structural characterisation of a cyprinid (Cyprinus carpio L.) CRH, CRH-BP and CRH-R1, and the role of these proteins in the acute stress response.},
  author={Mark O. Huising and Juriaan Rogier Metz and Carina J M van Schooten and Anja J. Taverne-Thiele and Trudi T. Hermsen and B. M. Lidy Verburg-van Kemenade and Gert Flik},
  journal={Journal of molecular endocrinology},
  year={2004},
  volume={32 3},
  pages={627-48}
}
We elucidated the structure of the principle factors regulating the initiation of the acute stress response in common carp: corticotrophin-releasing hormone (CRH), CRH-receptor 1 (CRH-R1) and CRH-binding protein (CRH-BP). Phylogenetic analyses reveal that these proteins are evolutionarily well conserved in vertebrates. CRH and CRH-BP expression are not co… CONTINUE READING