Structural changes induced by acidic pH in human apolipoprotein B-100

  title={Structural changes induced by acidic pH in human apolipoprotein B-100},
  author={Jos{\'e} {\'A}ngel Fern{\'a}ndez-Higuero and Asier Benito-Vicente and Aitor Etxebarria and Jos{\'e} Carlos G. Milicua and Helena Ostolaza and Jos{\'e} Luis R. Arrondo and C{\'e}sar Gavil{\'a}n Mart{\'i}n},
  booktitle={Scientific reports},
Acidification in the endosome causes lipoprotein release by promoting a conformational change in the LDLR allowing its recycling and degradation of LDL. Notwithstanding conformational changes occurring in the LDLR have expanded considerably, structural changes occurring in LDL particles have not been fully explored yet. The objectives of the present work were to study structural changes occurring in apoB100 by infrared spectroscopy (IR) and also LDL size and morphology by dynamic light… CONTINUE READING