Structural changes in the gut microbiome of constipated patients.

  title={Structural changes in the gut microbiome of constipated patients.},
  author={Lixin Zhu and Wensheng Liu and Razan H Alkhouri and Robert D. Baker and Jonathan E. Bard and Eamonn M M Quigley and Susan S. Baker},
  journal={Physiological genomics},
  volume={46 18},
Previous studies using culture-based methods suggested an association between constipation and altered abundance of certain taxa of the colonic microbiome. [] Key Method A cross-sectional pilot study using 16S rRNA gene pyrosequencing was performed to compare stool microbial composition of eight constipated patients and 14 nonconstipated controls. Only obese children were enrolled so that the microbiome features associated with constipation would not be obscured by those associated with obesity.

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