Structural changes in the gut microbiome of constipated patients.
@article{Zhu2014StructuralCI, title={Structural changes in the gut microbiome of constipated patients.}, author={Lixin Zhu and Wensheng Liu and Razan H Alkhouri and Robert D. Baker and Jonathan E. Bard and Eamonn M M Quigley and Susan S. Baker}, journal={Physiological genomics}, year={2014}, volume={46 18}, pages={ 679-86 } }
Previous studies using culture-based methods suggested an association between constipation and altered abundance of certain taxa of the colonic microbiome. [] Key Method A cross-sectional pilot study using 16S rRNA gene pyrosequencing was performed to compare stool microbial composition of eight constipated patients and 14 nonconstipated controls. Only obese children were enrolled so that the microbiome features associated with constipation would not be obscured by those associated with obesity.
224 Citations
Alteration of the faecal microbiota composition in patients with constipation: evidence of American Gut Project.
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Patients with constipation showed gut microbiota and butyrate metabolism dysbiosis, which might provide a reference for the diagnosis and clinical therapy of diseases.
Beneficial effects of lactitol on the composition of gut microbiota in constipated patients.
- MedicineJournal of digestive diseases
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AIM
To explore the changes in microbial composition and the corresponding impact after lactitol treatment in constipated patients.
METHODS
Twenty-nine consecutive outpatients diagnosed with chronic…
Mucosa-associated gut microbiome in Japanese patients with functional constipation.
- Medicine, BiologyJournal of clinical biochemistry and nutrition
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The mucosa-associated microbiome of functional constipation was characterized by higher levels of Bacteroidetes (Alistipes) and the proportion of genes responsible for sulfur metabolism, selenocompound metabolism, sulfur relay system and flavonoid biosynthesis was significantly lower.
Gut Microbiota Composition Changes in Constipated Women of Reproductive Age
- Medicine, BiologyFrontiers in Cellular and Infection Microbiology
- 2020
The overall composition of the gut microbiota changed in constipated women of reproductive age, characterized by a loss in Proteobacteria and an increase in Bacteroidetes, which may reflect the unique interactions between host and some bacteria, or some bacterial metabolic products which may be important targets for future studies to explore the pathogenesis of constipation.
Unveiling the gut microbiota composition and functionality associated with constipation through metagenomic analyses
- BiologyScientific Reports
- 2017
The gut microbiota of FC individuals was shown to be depleted of members belonging to Bacteroides, Roseburia and Coprococcus 3, and the metabolic capabilities of the gut microbiomes of five FC and five HS individuals were evaluated, indicating that HS are enriched in pathways involved in carbohydrate, fatty acid and lipid metabolism as compared to FC.
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- Medicine, BiologybioRxiv
- 2021
The aim was to identify microbial features associated with IBS and IBS subtypes compared to healthy controls and to determine if a synbiotic supplementation intervention could decrease the proportion of those microbial features.
Alteration of Gut Microbiota and Efficacy of Probiotics in Functional Constipation
- BiologyJournal of neurogastroenterology and motility
- 2015
were significantly less abundant in feces from patients with FC compared with healthy controls. However, no significant differences were observed regarding the proportion of Lactobacillus,…
Targeting patients' microbiota with probiotics and natural fibers in adults and children with constipation.
- BiologyEuropean review for medical and pharmacological sciences
- 2018
OBJECTIVE
Functional constipation (FC) is a common condition in which the gut microbiota composition plays a fundamental role. The increasing knowledge on the role of gut microbes in the regulation…
Analysis of fecal microbiota in patients with functional constipation undergoing treatment with synbiotics
- Medicine, BiologyEuropean Journal of Clinical Microbiology & Infectious Diseases
- 2017
Comparison of the microbiota among the three groups showed that Prevotella_9 was the characteristic bacteria that decreased in the constipation group and increased in the treatment group, and Identification of the key bacterial genus is important to reveal the mechanism and provide a reliable theoretical basis of synbiotic treatment.
Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility
- Medicine, BiologyScientific Reports
- 2017
It is suggested that alterations of the microbiome might affect gut motility via altered microbial-derived metabolites in the development of constipation, and the restoration of disturbed microbiota might improve the clinical phenotype.
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