Structural changes in the gut microbiome of constipated patients.

@article{Zhu2014StructuralCI,
  title={Structural changes in the gut microbiome of constipated patients.},
  author={Lixin Zhu and Wensheng Liu and Razan H Alkhouri and Robert D. Baker and Jonathan E. Bard and Eamonn M M Quigley and Susan S. Baker},
  journal={Physiological genomics},
  year={2014},
  volume={46 18},
  pages={
          679-86
        }
}
Previous studies using culture-based methods suggested an association between constipation and altered abundance of certain taxa of the colonic microbiome. [] Key Method A cross-sectional pilot study using 16S rRNA gene pyrosequencing was performed to compare stool microbial composition of eight constipated patients and 14 nonconstipated controls. Only obese children were enrolled so that the microbiome features associated with constipation would not be obscured by those associated with obesity.

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References

SHOWING 1-10 OF 53 REFERENCES

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

It is hypothesized that gut microbiota coevolved with the polysaccharide-rich diet of BF individuals, allowing them to maximize energy intake from fibers while also protecting them from inflammations and noninfectious colonic diseases.

Microbiota and SCFA in Lean and Overweight Healthy Subjects

The results contradict previous reports with regard to the contribution of various bacterial groups to the development of obesity and this issue remains controversial.

Defining the healthy "core microbiome" of oral microbial communities

It is shown that a major proportion of bacterial sequences of unrelated healthy individuals is identical, supporting the concept of a core microbiome at health.

Effect of Probiotics on Constipation, Fecal Azoreductase Activity and Fecal Mucin Content in the Elderly

Some relief from constipation may be observed with the combination of L. rhamnosus/P.

The intestinal ecosystem in chronic functional constipation

The results show that the constipated children presented a significant increase in clostridia and bifidobacteria in faeces compared to healthy subjects, and calcium polycarbophil treatment induced no significant changes in the composition of the intestinal ecosystem, nor in blood chemistry parameters.

Inflammation and intestinal metaplasia of the distal esophagus are associated with alterations in the microbiome.

In the human distal esophagus, inflammation and intestinal metaplasia are associated with global alteration of the microbiome, raising the issue of a possible role for dysbiosis in the pathogenesis of reflux-related disorders.

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

Alternative enterotype states are associated with long-term diet, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella) and other enterotypes distinguished primarily by levels of Bacteroide and Prevotella.

Methanobrevibacter smithii Is the Predominant Methanogen in Patients with Constipation-Predominant IBS and Methane on Breath

M. smithii is the predominant methanogen in C-IBS patients with methane on breath testing and the number and proportion of M.smithii in stool correlate well with amount of breath methane.

The Effects of Circumcision on the Penis Microbiome

The reduction in putative anaerobic bacteria after circumcision may play a role in protection from HIV and other sexually transmitted diseases, and the anoxic microenvironment of the subpreputial space may support pro-inflammatory anaerobes.

Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation.

...