Structural changes and fluctuations of proteins. II. Analysis of the denaturation of globular proteins.

@article{Kanehisa1977StructuralCA,
  title={Structural changes and fluctuations of proteins. II. Analysis of the denaturation of globular proteins.},
  author={M. I. Kanehisa and Akira Ikegami},
  journal={Biophysical chemistry},
  year={1977},
  volume={6 2},
  pages={131-49}
}
The statistical thermodynamic model of protein structure proposed in paper I is developed with special attention to the hydrophobic interaction. Calorimetric measurements of the thermal denaturation of five globular proteins, ribonuclease A, lysozyme, alpha-chymotrypsin, cytochrome c, and myoglobin, are quantitatively analyzed using the model. The thermodynamic parameters obtained by the least squares method reflect the global, average properties of proteins and are in good agreement with the… CONTINUE READING

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