Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?

  title={Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?},
  author={K. Prasad and M. Keshavan},
  journal={Schizophrenia bulletin},
  volume={34 4},
  • K. Prasad, M. Keshavan
  • Published 2008
  • Psychology, Medicine
  • Schizophrenia bulletin
  • Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest functional impairments associated with schizophrenia have been proposed as endophenotypes. However, few studies have examined the structural variations in the brain that might… CONTINUE READING
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