Structural cells are key regulators of organ-specific immune response

@article{Krausgruber2020StructuralCA,
  title={Structural cells are key regulators of organ-specific immune response},
  author={Thomas Krausgruber and Nikolaus Fortelny and Victoria Fife-Gernedl and Martin Senekowitsch and Linda Christina Schuster and Alexander Lercher and Amelie Nemc and Christian Schmidl and Andr{\'e} F. Rendeiro and Andreas Bergthaler and Christoph Bock},
  journal={Nature},
  year={2020},
  volume={583},
  pages={296 - 302}
}
The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens 1 . Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity 2 . However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence 3 – 5 . To advance our understanding of immunology outside the haematopoietic system, here… 

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References

SHOWING 1-10 OF 63 REFERENCES

Fibroblastic reticular cells at the nexus of innate and adaptive immune responses

This review will outline the current knowledge on FRC functions in secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches and will discuss how FRCs contribute to the regulation of immune processes in fat‐associated lymphoid clusters.

Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity

Examining ways in which stromal‐hematopoietic crosstalk has important consequences for regulating immune cell function within SLOs influences the adaptive immune response is examined.

A single-cell survey of the small intestinal epithelium

Intestinal epithelial cells absorb nutrients, respond to microbes, function as a barrier and help to coordinate immune responses. Here we report profiling of 53,193 individual epithelial cells from

Conservation and divergence in the transcriptional programs of the human and mouse immune systems

Two large compendia of transcriptional profiles of human and mouse immune cell types are compared, finding that global transcription profiles are conserved between corresponding cell lineages but to a lower degree, suggesting that distinct regulation may underlie some of the conserved transcriptional responses.

Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells

Current knowledge on the contribution of Ag-presenting LECs as regulators of peripheral T cell responses in different immunological contexts, including autoimmunity and cancer is reviewed and discussed.

Epithelium: at the interface of innate and adaptive immune responses.

Systems Immunology: Learning the Rules of the Immune System.

This work focuses on how natural variation is used to find patterns, infer principles, and develop predictive models for two areas: (a) immune cell activation-how single-cell profiling boosts the authors' ability to discover immune cell types and states-and (b) antigen presentation and recognition-how models can be generated to predict presentation of antigens on MHC molecules and their detection by T cell receptors.

Lineage-specific and single cell chromatin accessibility charts human hematopoiesis and leukemia evolution

The chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types that span the hematopoietic hierarchy are defined and 'enhancer cytometry' is enabled for enumeration of pure cell types from complex populations.
...