Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum.

@article{Staal2001StructuralBA,
  title={Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum.},
  author={Wouter Staal and Hilleke E. Hulshoff Pol and Hugo G. Schnack and Neeltje E.M . van Haren and Nathalie Seifert and Ren{\'e} S. Kahn},
  journal={The American journal of psychiatry},
  year={2001},
  volume={158 7},
  pages={1140-2}
}
OBJECTIVE This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia. METHOD Intracranial volume and volumes of the cerebrum, gray and white matter, lateral and third ventricles, frontal lobes, thalamus, and cerebellum were measured in 20 patients with a poor outcome, 25 with a favorable outcome, and 23 healthy comparison subjects with magnetic resonance imaging. RESULTS Thalamic volume was significantly smaller both in poor-outcome patients… CONTINUE READING