Structural biology of the aldo-keto reductase family of enzymes

  title={Structural biology of the aldo-keto reductase family of enzymes},
  author={Gulsah Sanli and Jocelyn I. Dudley and Michael Blaber},
  journal={Cell Biochemistry and Biophysics},
The aldo-keto reductases (AKR) comprise a large family of oxidoreductases with importance to both health and industrial applications. The redox chemistry of the AKRs is dependent on NAD(P)H as a cofactor. Despite a wealth of structural and biochemical data relating to the interaction of AKRs with specific inhibitors, much less is known regarding the interactions with cofactor or substrate. In particular, while many X-ray structures are available for AKR/inhibitor complexes, they are only a few… CONTINUE READING

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