Structural biology in drug design: selective protein kinase inhibitors.

  title={Structural biology in drug design: selective protein kinase inhibitors.},
  author={Giovanna Scapin},
  journal={Drug discovery today},
  volume={7 11},
Protein kinases have a fundamental role in signal transduction pathways, and aberrant kinase activity has been observed in many diseases. In recent years, kinase inhibition has become a major area for therapeutic intervention and a variety of kinase inhibitor pharmacophores has been described. This review illustrates some of the efforts and results in the field of structure-based design of protein kinase inhibitors. The methods and results discussed here illustrate the power of structure-based… CONTINUE READING

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