Structural biology and drug discovery for protein-protein interactions.

  title={Structural biology and drug discovery for protein-protein interactions.},
  author={Harry C Jubb and Alicia P. Higueruelo and Anja Winter and Tom L. Blundell},
  journal={Trends in pharmacological sciences},
  volume={33 5},
Although targeting protein-protein interfaces of regulatory multiprotein complexes has become a significant focus in drug discovery, it continues to pose major challenges. Most interfaces would be classed as 'undruggable' by conventional analyses, as they tend to be large, flat and featureless. Over the past decade, encouragement has come from the discovery of hotspots that contribute much of the free energy of interaction, and this has led to the development of tethering methods that target… CONTINUE READING

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