Structural biology: Wobble puts RNA on target

  title={Structural biology: Wobble puts RNA on target},
  author={Oscar Vargas-Rodriguez and Karin Musier-Forsyth},
Enzymes that attach amino acids to transfer RNAs during protein synthesis must recognize both substrates specifically. Crystal structures reveal a mechanism that explains the RNA specificity for one such system. See Article p.507 tRNA synthetases must attach the appropriate amino acid to the appropriate, cognate tRNA to maintain proper translation of the genetic code into protein. A single non-Watson–Crick base pair in the tRNA for alanine, G3·U70, ensures correct aminoacylation by the… Expand

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