Structural biology: A toolbox for protein design

@article{Hcker2012StructuralBA,
  title={Structural biology: A toolbox for protein design},
  author={Birte H{\"o}cker},
  journal={Nature},
  year={2012},
  volume={491},
  pages={204-205}
}
Some of the principles underlying how amino-acid sequences determine the three-dimensional structures of proteins have been defined. This has enabled a successful approach to designing protein folds from scratch. See Article p.222 When natural proteins folds to produce their unique biologically adapted structure, they do so despite the many energetically unfavorable non-ideal features — such as kinked helices, strained loops and buried polar groups — that arise in proteins as a result of… 
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