Structural bioinformatics of the interactome.

@article{Petrey2014StructuralBO,
  title={Structural bioinformatics of the interactome.},
  author={Donald Petrey and Barry Honig},
  journal={Annual review of biophysics},
  year={2014},
  volume={43},
  pages={193-210}
}
The past decade has seen a dramatic expansion in the number and range of techniques available to obtain genome-wide information and to analyze this information so as to infer both the functions of individual molecules and how they interact to modulate the behavior of biological systems. Here, we review these techniques, focusing on the construction of physical protein-protein interaction networks, and highlighting approaches that incorporate protein structure, which is becoming an increasingly… CONTINUE READING

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