Structural basis underlying the dual gate properties of KcsA.

  title={Structural basis underlying the dual gate properties of KcsA.},
  author={Shunsuke Imai and Masanori Osawa and Koh Takeuchi and Ichio Shimada},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 14},
KcsA is a prokaryotic pH-dependent potassium (K) channel. Its activation, by a decrease in the intracellular pH, is coupled with its subsequent inactivation, but the underlying mechanisms remain elusive. Here, we have investigated the conformational changes and equilibrium of KcsA by using solution NMR spectroscopy. Controlling the temperature and pH of… CONTINUE READING