Structural basis of transcription: separation of RNA from DNA by RNA polymerase II.

@article{Westover2004StructuralBO,
  title={Structural basis of transcription: separation of RNA from DNA by RNA polymerase II.},
  author={Kenneth D Westover and David A. Bushnell and Roger D. Kornberg},
  journal={Science},
  year={2004},
  volume={303 5660},
  pages={1014-6}
}
The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape. 
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