Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.

@article{Lee2014StructuralBO,
  title={Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.},
  author={C. Lee and Xiaofei Liang and Ramesh Gopalaswamy and Javaria Najeeb and Eugene D Ark and E. Toone and P. Zhou},
  journal={ACS chemical biology},
  year={2014},
  volume={9 1},
  pages={
          237-46
        }
}
The LpxC enzyme in the lipid A biosynthetic pathway is one of the most promising and clinically unexploited antibiotic targets for treatment of multidrug-resistant Gram-negative infections. Progress in medicinal chemistry has led to the discovery of potent LpxC inhibitors with a variety of chemical scaffolds and distinct antibiotic profiles. The vast majority of these compounds, including the nanomolar inhibitors L-161,240 and BB-78485, are highly effective in suppressing the activity of… Expand
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