Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.

@article{Yu1986StructuralBO,
  title={Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.},
  author={Chack Yung Yu and K. Tertia Belt and Carolyn M. Giles and Robert D. Campbell and Rodney R. Porter},
  journal={The EMBO journal},
  year={1986},
  volume={5 11},
  pages={2873-81}
}
The human complement components C4A and C4B are highly homologous proteins, but they show markedly different, class-specific, chemical reactivities. They also differ serologically in that C4A generally expresses the Rodgers (Rg) blood group antigens while C4B generally expresses the Chido (Ch) blood group antigens. C4A 1 and C4B 5 are exceptional variants which possess their class-specific chemical reactivities, but express essentially the reversed antigenicities. The genes encoding the typical… CONTINUE READING

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