Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex.

@article{Fukai2003StructuralBO,
  title={Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex.},
  author={Shuya Fukai and Hugo T Matern and Junutula R Jagath and Richard H. Scheller and Axel T Brunger},
  journal={The EMBO journal},
  year={2003},
  volume={22 13},
  pages={3267-78}
}
The sec6/8 complex or exocyst is an octameric protein complex that functions during cell polarization by regulating the site of exocytic vesicle docking to the plasma membrane, in concert with small GTP-binding proteins. The Sec5 subunit of the mammalian sec6/8 complex binds Ral in a GTP-dependent manner. Here we report the crystal structure of the complex between the Ral-binding domain of Sec5 and RalA bound to a non-hydrolyzable GTP analog (GppNHp) at 2.1 A resolution, providing the first… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
46 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…