Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway

  title={Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway},
  author={Eunha Hwang and H K Cheong and Ameeq Ul Mushtaq and Hye-Yeon Kim and Kwon Joo Yeo and Eunhee Kim and Woo Cheol Lee and Kwang Yeon Hwang and Chaejoon Cheong and Young Ho Jeon},
  booktitle={Acta crystallographica. Section D, Biological crystallography},
Despite recent progress in research on the Hippo signalling pathway, the structural information available in this area is extremely limited. Intriguingly, the homodimeric and heterodimeric interactions of mammalian sterile 20-like (MST) kinases through the so-called `SARAH' (SAV/RASSF/HPO) domains play a critical role in cellular homeostasis, dictating the fate of the cell regarding cell proliferation or apoptosis. To understand the mechanism of the heterodimerization of SARAH domains, the… CONTINUE READING
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MST–RASSF SARAH heterodimer


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