Structural basis of the gp120 superantigen-binding site on human immunoglobulins.

  title={Structural basis of the gp120 superantigen-binding site on human immunoglobulins.},
  author={Saoussen Karray and Laure Juompan and Rachid C. Maroun and David Isenberg David Isenberg and Gregg J Silverman and Moncef Zouali},
  journal={Journal of immunology},
  volume={161 12},
B cell superantigens (SAg) interact with normal human nonimmune Igs (Igs), independently of the light chain isotype, and activate a large proportion of the B cell repertoire. Recently, the major envelope protein of HIV-1, gp120, was found to exhibit SAg-like properties for B cells with potential pathologic consequences for the infected host. This unconventional mode of interaction contrasts with its binding to immunization-induced Abs, which requires the tertiary structure of the heavy and… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 65 references

Genetic, structural and functional properties of a human IgG anti-DNA autoantibody.Eur

C. T. Ravirajan, M. A. Rhaman, +6 authors D. A. Isenberg
J. Immunol • 1998

Selective deficit in antibodies specific for the superantigen binding site of gp120 in HIV infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1998

Analysis of the human VH gene repertoire : differential effects of selection and somatic hypermutation on human peripheral CD 5 ( 1 ) / IgM 1 and CD 5 ( 2 ) / IgM 1 B cells

H. P. Brezinschek, R. I. Brezinschek, T. Dorner, S. R. Domiati, P. E. Lipsky
J . Immunol . • 1997

B-cell superantigens.

Immunology today • 1997
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