Structural basis of the drug-binding specificity of human serum albumin.

@article{Ghuman2005StructuralBO,
  title={Structural basis of the drug-binding specificity of human serum albumin.},
  author={Jamie Ghuman and Patricia A. Zunszain and Isabelle Petitpas and Ananyo A. Bhattacharya and Masaki Otagiri and Stephen Curry},
  journal={Journal of molecular biology},
  year={2005},
  volume={353 1},
  pages={
          38-52
        }
}

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The crystal structures of HSA-myristate complexed with the R-(+) and S-(−) enantiomers of warfarin, a widely used anticoagulant that binds to the protein with high affinity, confirm that warFarin binds to drug site I (in subdomain IIA) in the presence of fatty acids and reveal the molecular details of the protein-drug interaction.
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