Structural basis of the day-night transition in a bacterial circadian clock

  title={Structural basis of the day-night transition in a bacterial circadian clock},
  author={Roger Tseng and Nicolette F Goularte and Archana Chavan and Jansen Luu and Susan E Cohen and Yong-Gang Chang and Joel Heisler and Sheng Li and Alicia K. Michael and Sarvind M Tripathi and Susan S Golden and Andy LiWang and Carrie L Partch},
Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a set of output signaling proteins, SasA and CikA, which transduce this rhythm to control gene expression. Here, we describe crystal and nuclear magnetic resonance structures of KaiB-KaiC,KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 46 times over the past 90 days. VIEW TWEETS