Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.

@article{Suzuki2014StructuralBO,
  title={Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.},
  author={Hironori Suzuki and Keisuke Tabata and Eiji Morita and Masato Kawasaki and Ryuichi Kato and Renwick C J Dobson and Tamotsu Yoshimori and Soichi Wakatsuki},
  journal={Structure},
  year={2014},
  volume={22 1},
  pages={47-58}
}
Autophagy is a bulk degradation pathway that removes cytosolic materials to maintain cellular homeostasis. The autophagy-related gene 13 (Atg13) and microtubule associate protein 1 light chain 3 (LC3) proteins are required for autophagosome formation. We demonstrate that each of the human LC3 isoforms (LC3A, LC3B, and LC3C) interacts with Atg13 via the LC3 interacting region (LIR) of Atg13. Using X-ray crystallography, we solved the macromolecular structures of LC3A and LC3C, along with the… CONTINUE READING
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