Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.


Autophagy is a bulk degradation pathway that removes cytosolic materials to maintain cellular homeostasis. The autophagy-related gene 13 (Atg13) and microtubule associate protein 1 light chain 3 (LC3) proteins are required for autophagosome formation. We demonstrate that each of the human LC3 isoforms (LC3A, LC3B, and LC3C) interacts with Atg13 via the LC3… (More)
DOI: 10.1016/j.str.2013.09.023