Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4†

@inproceedings{Suzuki2009StructuralBO,
  title={Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4†},
  author={Yoko Suzuki and Akiko Noma and Tsutomu Suzuki and Ryuichiro Ishitani and Osamu Nureki},
  booktitle={Nucleic acids research},
  year={2009}
}
Wybutosine (yW), one of the most complicated modified nucleosides, is found in the anticodon loop of eukaryotic phenylalanine tRNA. This hypermodified nucleoside ensures correct codon recognition by stabilizing codon-anticodon pairings during the decoding process in the ribosome. TYW4 is an S-adenosylmethionine (SAM)-dependent enzyme that catalyzes the final step of yW biosynthesis, methylation and methoxycarbonylation. However, the structural basis for the catalytic mechanism by TYW4, and… CONTINUE READING

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