Structural basis of substrate recognition and specificity in the N-end rule pathway

@article{MattaCamacho2010StructuralBO,
  title={Structural basis of substrate recognition and specificity in the N-end rule pathway},
  author={Edna Matta-Camacho and Guennadi Kozlov and Flora F Li and Kalle Gehring},
  journal={Nature Structural &Molecular Biology},
  year={2010},
  volume={17},
  pages={1182-1187}
}
The N-end rule links the half-life of a protein to the identity of its N-terminal residue. Destabilizing N-terminal residues are recognized by E3 ubiquitin ligases, termed N-recognins. A conserved structural domain called the UBR box is responsible for their specificity. Here we report the crystal structures of the UBR boxes of the human N-recognins UBR1… CONTINUE READING