Structural basis of spirolactone recognition by the mineralocorticoid receptor.

  title={Structural basis of spirolactone recognition by the mineralocorticoid receptor.},
  author={Jessica Huyet and Gr{\'e}gory Maurice Pinon and Michel Raymond Fay and J{\'e}r{\^o}me Fagart and Marie-Edith Rafestin-Oblin},
  journal={Molecular pharmacology},
  volume={72 3},
Spirolactones are potent antagonists of the mineralocorticoid receptor (MR), a ligand-induced transcription factor belonging to the nuclear receptor superfamily. Spirolactones are synthetic molecules characterized by the presence of a C17 gamma-lactone, which is responsible for their antagonist character. They harbor various substituents at several positions of the steroid skeleton that modulate their potency in ways that remain to be determined. This is particularly obvious for C7 substituents… CONTINUE READING


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