Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.

@article{Fontes2000StructuralBO,
  title={Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-alpha.},
  author={Marcos R M Fontes and Trazel Teh and Bostjan Kobe},
  journal={Journal of molecular biology},
  year={2000},
  volume={297 5},
  pages={
          1183-94
        }
}
  • Marcos R M Fontes, Trazel Teh, Bostjan Kobe
  • Published in Journal of molecular biology 2000
  • Biology, Medicine
  • Importin-alpha is the nuclear import receptor that recognizes cargo proteins which contain classical monopartite and bipartite nuclear localization sequences (NLSs), and facilitates their transport into the nucleus. To determine the structural basis of the recognition of the two classes of NLSs by mammalian importin-alpha, we co-crystallized an N-terminally truncated mouse receptor protein with peptides corresponding to the monopartite NLS from the simian virus 40 (SV40) large T-antigen, and… CONTINUE READING

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