Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems.

@article{Wess1997StructuralBO,
  title={Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems.},
  author={Juergen Wess and J Liu and Nikolaus Blin and J Yun and Christian Lerche and Evi Kostenis},
  journal={Life sciences},
  year={1997},
  volume={60 13-14},
  pages={
          1007-14
        }
}
Different muscarinic acetylcholine receptor subtypes were used as model systems to study the structural basis of receptor/G protein coupling selectivity. Extensive mutagenesis studies have previously led to the identification of single amino acids on the m3 muscarinic receptor protein (located in the second intracellular loop (i2) and at the N- and C-terminus of the third intracellular loop (i3)) that dictate selective recognition of Gq/11 proteins by this receptor subtype. Based on these… CONTINUE READING

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