Structural basis of protein phosphatase 2A stable latency

@inproceedings{Jiang2013StructuralBO,
  title={Structural basis of protein phosphatase 2A stable latency},
  author={Lei Jiang and Vitali Stanevich and Kenneth A. Satyshur and Mei Kong and Guy R. Watkins and Brian E. Wadzinski and Rituparna Sengupta and Yongna Xing},
  booktitle={Nature communications},
  year={2013}
}
The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report the structure of α4 bound to the N-terminal fragment of PP2Ac. This structure suggests that α4 binding to the full-length PP2Ac requires local unfolding near the active site, which perturbs the scaffold subunit binding site at the opposite surface via allosteric relay. These changes stabilize an… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

PP2A as a master regulator of the cell cycle.

  • Critical reviews in biochemistry and molecular biology
  • 2016
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

the atomic coordinates of the nPP2Ac–a4 complex have been deposited in the Protein Data Bank under accession code 4IYP

D. D. Weis, J. R. Engen, +14 authors wrote the manuscript. Additional information Accession codes
  • Supplementary Information accompanies this paper at http://www.nature.com/ naturecommunications Competing financial interests: The authors declare no competing financial interests. Reprints and permission information is available online at http://npg.nature.com/ reprintsandpermissions/ How to cite t
  • 2013

Overview of the CCP4 suite and current developments

Winn, D M.
  • Acta Crystallogr. D Biol. Crystallogr
  • 2011

The structural basis for tight control of PP2A methylation and function by LCMT-1

V Stanevich
  • Mol. Cell 41,
  • 2011

alpha4 is highly expressed in carcinogen-transformed human cells and primary human cancers

Chen, P L.
  • Oncogene 30,
  • 2011

Similar Papers

Loading similar papers…