Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster

@inproceedings{Akif2012StructuralBO,
  title={Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster},
  author={Mohd Akif and Geoffrey Masuyer and Richard J Bingham and Edward D. Sturrock and R Elwyn Isaac and K Ravi Acharya},
  booktitle={The FEBS journal},
  year={2012}
}
UNLABELLED Human somatic angiotensin-1 converting enzyme (ACE) is a zinc-dependent exopeptidase, that catalyses the conversion of the decapeptide angiotensin I to the octapeptide angiotensin II, by removing a C-terminal dipeptide. It is the principal component of the renin-angiotensin-aldosterone system that regulates blood pressure. Hence it is an important therapeutic target for the treatment of hypertension and cardiovascular disorders. Here, we report the structures of an ACE homologue from… CONTINUE READING
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