Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice.

Abstract

We have determined the crystal structure of I-Ag7, an integral component in murine type I diabetes development. Several features distinguish I-Ag7 from other non-autoimmune-associated MHC class II molecules, including novel peptide and heterodimer pairing interactions. The binding groove of I-Ag7 is unusual at both terminal ends, with a potentially solvent… (More)

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