Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

@article{Fusco2017StructuralBO,
  title={Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers},
  author={Giuliana Fusco and Serene W Chen and Philip T F Williamson and Roberta Cascella and Michele Perni and James A. Jarvis and Cristina Cecchi and Michele Vendruscolo and Fabrizio Chiti and Nunilo Cremades and Liming Ying and Christopher M. Dobson and Alfonso De Simone},
  journal={Science},
  year={2017},
  volume={358},
  pages={1440-1443}
}
Oligomeric species populated during the aggregation process of α-synuclein have been linked to neuronal impairment in Parkinson’s disease and related neurodegenerative disorders. By using solution and solid-state nuclear magnetic resonance techniques in conjunction with other structural methods, we identified the fundamental characteristics that enable toxic α-synuclein oligomers to perturb biological membranes and disrupt cellular function; these include a highly lipophilic element that… CONTINUE READING
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