Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase.

@article{Li2000StructuralBO,
  title={Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase.},
  author={Shaoying Li and Seamus J Kelly and Ejvis Lamani and Marta Ferraroni and Mark J Jedrzejas},
  journal={The EMBO journal},
  year={2000},
  volume={19 6},
  pages={1228-40}
}
Streptococcus pneumoniae hyaluronate lyase (spnHL) is a pathogenic bacterial spreading factor and cleaves hyaluronan, an important constituent of the extra- cellular matrix of connective tissues, through an enzymatic beta-elimination process, different from the hyaluronan degradation by hydrolases in animals. The mechanism of hyaluronan binding and degradation was proposed based on the 1.56 A resolution crystal structure, substrate modeling and mutagenesis studies on spnHL. Five mutants, R243V… CONTINUE READING

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PROCHECK: a program to check the stereochemical quality of protein structures

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