Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae.

@article{Izor2010StructuralBO,
  title={Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae.},
  author={Thierry Izor{\'e} and Carlos Contreras-Martel and Lamya El Mortaji and Clothilde Manzano and R{\'e}my Terrasse and Thierry Vernet and Anne Marie Di Guilmi and Andr{\'e}a Dessen},
  journal={Structure},
  year={2010},
  volume={18 1},
  pages={106-15}
}
Pili are fibrous virulence factors associated directly to the bacterial surface that play critical roles in adhesion and recognition of host cell receptors. The human pathogen Streptococcus pneumoniae carries a single pilus-related adhesin (RrgA) that is key for infection establishment and provides protection from bacterial challenge in animal infection models, but details of these roles remain unclear. Here we report the high-resolution crystal structure of RrgA, a 893-residue elongated… CONTINUE READING

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