Structural basis of high fidelity DNA synthesis by yeast DNA polymerase delta

@inproceedings{Swan2009StructuralBO,
  title={Structural basis of high fidelity DNA synthesis by yeast DNA polymerase delta},
  author={Michael Kenneth Swan and Robert E. Johnson and L. T. Om Prakash and Satya Prakash and Aneel K. Aggarwal},
  booktitle={Nature Structural &Molecular Biology},
  year={2009}
}
DNA polymerase δ (Pol δ) is a high-fidelity polymerase that has a central role in replication from yeast to humans. We present the crystal structure of the catalytic subunit of yeast Pol δ in ternary complex with a template primer and an incoming nucleotide. The structure, determined at 2.0-Å resolution, catches the enzyme in the act of replication, revealing how the polymerase and exonuclease domains are juxtaposed relative to each other and how a correct nucleotide is selected and… CONTINUE READING

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