Structural basis of hepatocyte growth factor/scatter factor and MET signalling.

@article{Gherardi2006StructuralBO,
  title={Structural basis of hepatocyte growth factor/scatter factor and MET signalling.},
  author={Ermanno Gherardi and Sara Sandin and Maxim V. Petoukhov and John M. Finch and Mark E Youles and L G Ofverstedt and Ricardo N{\'u}{\~n}ez Miguel and Tom L. Blundell and George F. Vande Woude and Ulf Skoglund and Dmitri I. Svergun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 11},
  pages={
          4046-51
        }
}
The polypeptide growth factor, hepatocyte growth factor/scatter factor (HGF/SF), shares the multidomain structure and proteolytic mechanism of activation of plasminogen and other complex serine proteinases. HGF/SF, however, has no enzymatic activity. Instead, it controls the growth, morphogenesis, or migration of epithelial, endothelial, and muscle progenitor cells through the receptor tyrosine kinase MET. Using small-angle x-ray scattering and cryo-electron microscopy, we show that conversion… CONTINUE READING

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